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Kamis, 14 Desember 2017

Superficial spreading melanoma - Wikipedia
src: upload.wikimedia.org

Superficial spreading melanoma (also known as "superficially spreading melanoma") (SSM) is usually characterized as the most common form of cutaneous melanoma in Caucasians. The average age at diagnosis is in the fifth decade, and it tends to occur on sun-exposed skin, especially on the backs of males and lower limbs of females.


Video Superficial spreading melanoma



Presentation

Often, this disease evolves from a precursor lesion, usually a dysplastic nevus. Otherwise it arises in previously normal skin. A prolonged radial growth phase, where the lesion remains thin, may eventually be followed by a vertical growth phase where the lesion becomes thick and nodular. As the risk of spread varies with the thickness, early SSM is more frequently cured than late nodular melanoma.

The microscopic hallmarks are:

  • Large melanocytic cells with nest formation along the dermo-epidermal junction.
  • Invasion of the upper epidermis in a pagetoid fashion (discohesive single cell growth).
  • The pattern of rete ridges is often effaced.
  • Invasion of the dermis by atypical, pleomorphic melanocytes
  • Absence of the 'maturation' typical of naevus cells
  • Mitoses

Maps Superficial spreading melanoma



Treatment

Treatment is by excisional biopsy, wide local excision and possibly sentinel node biopsy. Spread of disease to local lymph nodes or distant sites (typically brain, bone, skin and lung) marks a decidedly poor prognosis.


SUPERFICIAL SPREADING MELANOMA
src: www.regionalderm.com


See also

  • Melanoma
  • List of cutaneous conditions

Superficial spreading melanoma with dermoscopic features | Dermpedia
src: www.dermpedia.org


References


SUPERFICIAL SPREADING MELANOMA
src: www.regionalderm.com


External links

  • Fact File from the Royal College of Pathologists of Australasia (pdf)

Source of the article : Wikipedia

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